In vivo comparison between the effects of chemically modified hydrophilic and anodically oxidized titanium surfaces on initial bone healing
이효정, 양일형, 김성균, 여인성, 권택기,
소속 상세정보
이효정 ( Lee Hyo-Jung ) - Seoul National University Bundang Hospital Section of Dentistry Department of Periodontology
양일형 ( Yang Il-Hyung ) - Seoul National University School of Dentistry Department of Orthodontics
김성균 ( Kim Seong-Kyun ) - Seoul National University School of Dentistry Department of Prosthodontics
여인성 ( Yeo In-Sung ) - Seoul National University School of Dentistry Department of Prosthodontics
권택기 ( Kwon Taek-Ka ) - Catholic University St. Vincent Hospital Department of Prosthetic Dentistry
KMID : 0363020150450030094
Abstract
Purpose: The aim of this study was to investigate the combined effects of physical and chemical surface factors on in vivo bone responses by comparing chemically modified hydrophilic sandblasted, large-grit, acid-etched (modSLA) and anodically oxidized hydrophobic implant surfaces.
Methods: Five modSLA implants and five anodized implants were inserted into the tibiae of five New Zealand white rabbits (one implant for each tibia). The characteristics of each surface were determined using field emission scanning electron microscopy, energy dispersive spectroscopy, and confocal laser scanning microscopy before the installation. The experimental animals were sacrificed after 1 week of healing and histologic slides were prepared from the implant-tibial bone blocks removed from the animals. Histomorphometric analyses were performed on the light microscopic images, and bone-to-implant contact (BIC) and bone area (BA) ratios were measured. Nonparametric comparison tests were applied to find any significant differences (P<0.05) between the modSLA and anodized surfaces.
Results: The roughness of the anodized surface was 1.22 ± 0.17 μm in Sa, which was within the optimal range of 1.0-2.0 μm for a bone response. The modSLA surface was significantly rougher at 2.53 ± 0.07 μm in Sa. However, the modSLA implant had significantly higher BIC than the anodized implant (P=0.02). Furthermore, BA ratios did not significantly differ between the two implants, although the anodized implant had a higher mean value of BA (P>0.05).
Conclusions: Within the limitations of this study, the hydrophilicity of the modSLA surface may have a stronger effect on in vivo bone healing than optimal surface roughness and surface chemistry of the anodized surface.
키워드
Animal experimentation ; Dental implants ; Histology ; Osseointegration
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